The 17-year-old beauty, who is taking the reigns from singer Rita Ora, will appear in the 'Boardwalk Babe' adverts showing the American actress and singer on the famous Coney Island boardwalk in Brooklyn, modelling the line's cute summer collection.
Speaking of the collaboration, Madonna said: 'Zendaya exudes a confident, free spirit. We love having her as the new face of Material Girl.'
Madonna's daughter, Lourdes Leon, who models the Material Girl clothing and works alongside her mother, also gushed about the new model.
She said: 'I love how Zendaya makes her own style rules to fit her personality - that's who Material Girl is all about, being yourself to the fullest.'
Zendaya was thrilled to be chosen by the 'dynamic mother/daughter duo'.
She commented: 'Material Girl embraces having fun with fashion and being confident in your own skin ... and who does that better than Madonna?'
The 'Shake It Up' singer is also following in the footsteps of former Material Girls, singer Taylor Momsen and model Georgia May Jagger.
Zendaya's career is going from strength to strength and she is also set to play the late R&B star Aaliyah in a new Lifestime TV biopic, 'Aaliyah: Princess of R&B', which was announced this week.