If 'MDNA' lands atop the list, it will mark the queen of pop's eighth No. 1 album and her fifth consecutive studio set to debut in the penthouse. Her last studio album, 2008's 'Hard Candy,' started at No. 1 with 280,000 sold according to Nielsen SoundScan.
The new Billboard 200 chart's top 10 will be revealed on the morning of Wednesday, April 4.
Madonna's first No. 1 came on the Billboard 200 chart dated Feb. 9, 1985, when her second album, 'Like a Virgin,' began a three-week run at the top.
'MDNA's' first week will be bolstered by a successful album sales promotion involving Madonna's upcoming world tour. U.S. customers who bought a concert ticket also had the option of also receiving 'MDNA' as part of their purchase. The only sales that will count towards Billboard's charts are those where the customer opted to receive the album.